Body Lift

Description

Body Lift is a preventative and corrective treatment for stretch marks. By helping in inhibit the harmful effects of various proteolytic enzymes (elastase, trypsin, chymotrypsin) involved in the formulation of stretch marks and suppression of the synthesis of skin matrix molecules (collagen, fibronectin). rejuvaDERM Body Lift enables skin to recover more rapidly and effectively from the trauma of being forcibly extended. While maintaining skin firmness by inhibition of the enzyme hyalurondisase, which is responsible for the breakdown of Hyaluronic Acid in the skin resulting in the loss of firmness, elasticity and smoothness. The third element of rejuvaDERM Body Lift stimulates tissue regeneration by way of collagen matrix build up. Couple this with the latest 24 hour moisturizing technology and you had a powerful formula to assist in the correction of stretch marks. It also contains powerful bleaching elements to fade stretch marks restore and restore normal dermal clarity.

Directions for Use

Every day after shower or bath, apply a small amount to the entire body for a smooth and silky skin. Massage in light circular movements concentrating and insisting on the areas where there are stretch marks. Leave on your skin until the next shower.

Ingredients

D-alpha Tocopherol Acetate	Vitamin E	Moisturising and anti oxidant properties.
Palmitoyl Oligopeptide Palmitoyl Tetrapeptide-3		Contains matrikines that are messengers of cutaneous restructuration and repair. They activate the neosynthesis of extracellular matrix macromolecules providing a visible anti-wrinkle efficacy.
Palmitoyl-Tetrapeptide-7 Rutin Phaseolus Lunatus (Green Bean) Extract		The inflammatory reaction begins before Stretch marks are visible and continues as they appear on the skin from a pink colour fading to white. This prevents and reduces stretch marks by slowing down the degradation and by promoting regeneration of the extracellular matrix.
Bearberry (Arctostaphylos Uva Ursi) Extract Mitracarpus Scaber Extract		Is an active ingredient designed for the treatment of pigmentary spots and cutaneous discolouration problems. Its activity based on African ethnobotanical experience is confirmed by a strong tyrosinase inhibitory activity in vitro and ex vivo.
Imperata Cylindrica (Root Extract)		Imperata cylindrical provides the skin with considerable hydration. Potassium and DMSP help cells maintain their osmotic equilibrium. The synergistic effect has been exploited to produce a high, immediate and long-lasting moisturizing effect.
Centella asiatica extract	Gotu Kola	To aid wound healing stimulate the production of type 1 collagen and results in a marked decrease in inflammatory reaction and myofibroblast production.
Siegesbeckia orientalis Extract		The active constituent has a crystalline structure akin to that of aspirin (salicylic acid) and is responsible for its sedative and soothing action.
Undaria & Pinnatifida Extract		Maintains skin firmness, elasticity and smoothness, supports skin regeneration, defends against environmental stress.
PH Levels: 5.5 – 6.0 Size: 150ml

Clinical Data: Registril

Inhibition of enzymes
During the inflammatory phase contributing to the formation of stretch marks, proteolytic enzymes are released such as Trypsin, chymotrypsin (mast cell degranulation) and leukocyte Elastase (macrophages). Trypsin, chymotrypsin or elastase are Incubated with REGESTRIL tm at different concentrations.
The inhibition kinetics are monitored for a few
REGESTRIL tm inhibits, in a dose-dependent and significant
Manner, the proteolytic enzymes released during the formation
Of the stretch mark.

Synthesis of matrix macromolecules Human fibroblasts are
Incubated with REGESTRIL tm at 2%. After incubation, the
Collagen 1 and the fibronectin produced are quantified by immuno
Dosage and visualized by immuno fluorescence.

Synethesis of collagen 1…………………….+102%
Synthesis of fibronectin……………………..+ 91%

REGESTRIL tm fights against the degradation of the Extracellular matrix contributing to the formation of stretch marks by:

antagonizing the destructive effect of proteolytic enzymes.
Stimulating the neosynthesis of the matrix macromolecules.

Enzymatic activities	Regestril
	1%	2%	3%	4%
Trypsin	-4%	-14%	-32%	-58%
Chymotrypsin	-3%	-7%	-11%	-15%
Elastase	-41%	-66%	-80%	-90%

Stimulation of fibronectin synthesis

Stimulation of collagen synthesis

Anti-stretch mark efficacy:

13 women with stretch marks on the abdominal area (post pregnancy) / Twice daily application of a cream
Containing 2% REGESTRIL tm /56 days / the anti-stretch mark efficacy was assessed by echography and
Dermatological evaluation.

Colour	-21.7%	p<9.05
Relief	-21.9%	p<0.05
Width	-26.7%	p<0.05
Skin thickness	+10.8%	p<0.05
Stretch mark depression	-72.5%	p=0.07

REGESTRIL tm shows a visible and significant anti-stretch mark efficacy. After 2 months use, stretch marks fade and skin becomes smoother.